NMN Reverse the Effects of Alzheimer’s Disease in Mice

Nicotinamide mononucleotide (NMN) reverses the effects of Alzheimer’s disease in mice, making it a potential intervention for the disease.

· Scientific Research,Neurological
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By Brett J. Weiss

Published: 3:42 p.m. PST May 1, 2017 | Updated: 11:45 am PST Sep 22, 2020

An estimated 5.7 million Americans lived with Alzheimer’s disease in 2018, according to the Centers for Disease Control (CDC). Alzheimer’s disease can seriously affect one’s ability to perform daily activities and involves a deterioration in parts of the brain controlling thought, memory, and language.

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(Yao et al., 2017 | Neuroscience letters) Mice with Alzheimer’s disease perform better on a task measuring cognition following NMN. WT denotes normal mice and Tg means mice with Alzheimer’s disease. The bar on the far-right side shows mice with Alzheimer’s disease administered NMN performing almost as well as normal mice.

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(Yao et al., 2017 | Neuroscience letters) NMN reduces the plaque build up in the brains of mice with Alzheimer’s disease. The image on the left shows the brown plaque build ups in mice with Alzheimer’s disease. The image on the right shows the reduction in brown plaque build up following NMN treatment in mice with Alzheimer’s disease.

NMN treatment improved neural inflammation in mice with Alzheimer’s disease. Levels of molecules associated with neural inflammation were presented at lower levels in mice with Alzheimer’s disease treated with NMN compared to those not treated with NMN.

“According to our findings, NMN could be a new target for disease-modifying treatments in [Alzheimer’s disease],” stated the authors in their study. With substantially improving cognitive function, lowering amyloid plaque build up, and improving neuroinflammation in mice, NMN could provide a valuable therapeutic option for Alzheimer’s disease in the future.


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Yao Z, Yang W, Gao Z, Jia P. Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease. Neurosci Lett. 2017;647:133-140. doi:10.1016/j.neulet.2017.03.027

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